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In vitro cytotoxicity profiles of (A) rhein (RH), (B) rhein-bilosomes (BIL), and (C) rhein-limobilosomes (L-BIL) against <t>A375</t> melanoma cells and HDFa normal cell lines. The figure was generated by GraphPad Prism and retouched by Adobe Illustrator.
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In vitro cytotoxicity profiles of (A) rhein (RH), (B) rhein-bilosomes (BIL), and (C) rhein-limobilosomes (L-BIL) against <t>A375</t> melanoma cells and HDFa normal cell lines. The figure was generated by GraphPad Prism and retouched by Adobe Illustrator.
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In vitro cytotoxicity profiles of (A) rhein (RH), (B) rhein-bilosomes (BIL), and (C) rhein-limobilosomes (L-BIL) against A375 melanoma cells and HDFa normal cell lines. The figure was generated by GraphPad Prism and retouched by Adobe Illustrator.

Journal: Frontiers in Pharmacology

Article Title: A dual edge-activation strategy for rhein bilosomes enhances intradermal delivery and anti-melanoma efficacy

doi: 10.3389/fphar.2026.1798385

Figure Lengend Snippet: In vitro cytotoxicity profiles of (A) rhein (RH), (B) rhein-bilosomes (BIL), and (C) rhein-limobilosomes (L-BIL) against A375 melanoma cells and HDFa normal cell lines. The figure was generated by GraphPad Prism and retouched by Adobe Illustrator.

Article Snippet: For the cytotoxicity study, A375 human melanoma cell line was obtained from ATCC, Virginia, United States, while dimethyl sulfoxide was obtained from ThermoFisher Scientific, USA, and PBS was obtained from Biowest, USA.

Techniques: In Vitro, Generated